Lifeasible, a biotechnology company specialized in agricultural science, has accumulated decades of experience in plant genetic engineering. Based on CRISPR/CAS9, Lifeasible has developed a transgenic plant platform to provide engineered plants with enhanced properties such as high yields and nutrients, resistance to disease, pests, or drought tolerance.
CRISPR/Cas9 gene editing is a technique for rapid editing of genomic DNA with very high efficiency and specificity, and its mechanism is the same as that used by prokaryotes to defend against viral or other foreign DNA invasion. Cas9 is an RNA-guided DNA endonuclease associated with CRISPR. SgRNAs (single-guideRNAs) are packaged with multiple crRNAs and tracrRNA that can bind Cas9 and direct this complex to complementary sequences in the target DNA. The simple design of sgRNAs strictly follows Watson-Crick base pairing, making CRISPR/Cas9 a very effective and promising gene editing tool.
Lifeasible has a professional molecular biology laboratory with cutting-edge instruments. Cell and molecular biology experts at Lifeasible are committed to providing industry-leading customized sgRNA design and vector construction services to customers worldwide. The company can provide single and multiple gene knockouts, knock-outs or knock-ins, site-specific mutations or even single nucleotide mutations based on alternative DNA repair pathways.
Lifeasible can also perform high-throughput screening by sgRNA library. With mature transgenic technologies in various species such as Arabidopsis, rice, wheat, alfalfa, corn, cotton, sorghum, soybean, sugar beet, cabbage, tobacco, eggplant, cucumber, potato, petunia, and rapeseed, Lifeasible has the ability to meet different requirements for our customers.
“We address the genetic modification of plants through multiple popular genetic engineering technologies, including CRISPR/CAS9, CRISPR base editors, transcription activator-like effector nucleases (TALENs), zinc finger nucleases (ZFNs), RNA interference (RNAi), virus-induced gene silencing (VIGS), and gene overexpression, etc.” said one of the representative speakers from Lifeasible.
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